Expression of angiogenesis-related factors in human corneas after cultivated oral mucosal epithelial transplantation
Investigative Ophthalmology & Visual Science, 08/02/2012
Chen HCJ et al. – Expression of FGF–2, VEGF, PEDF, endostatin, and IL–1ra was similar in normal corneas, conjunctiva, oral mucosa, and corneas after COMET. Expression of sFlt–1, TIMP–3, and TSP–1 was limited to normal corneas and negative for other tissues. A lack of the aforementioned anti–angiogenic factors may contribute to the peripheral corneal neovascularization seen after COMET.