The prostacyclin agonist iloprost aggravates fibrosis and enhances viral replication in enteroviral myocarditis by modulation of ERK signaling and increase of iNOS expression
Basic Research in Cardiology , 08/20/2012
Gruhle S et al. – The authors confirmed these results, proving that iloprost potentiates the expression of inducible nitric oxide synthase (iNOS) mRNA and protein in CVB3–infected and IFN–gamma stimulated bone marrow macrophages (BMM). In conclusion, these results suggest a critical reflection of the clinical use of iloprost, especially in patients possibly suffering from an enteroviral myocarditis.