Impact of the AT2 Receptor Agonist C21 on Blood Pressure and Beyond
Current Hypertension Reports, 08/17/2012
Foulquier S et al. – This article reviews the impact of C21 on blood pressure in normotensive and hypertensive animal models. Although C21 does not act as a classical antihypertensive drug, it could be useful in preventing hypertension–induced vascular and other end organ damages via anti–apoptotic, anti–fibrotic and anti–inflammatory actions. In particular, a strong body of evidence started to emerge around its anti–inflammatory feature. This property should be further investigated for potential clinical indications in cardiovascular diseases and beyond.