Phase I clinical trial of Mixed Bacterial Vaccine (Coley's Toxins) in patients with NY-ESO-1 expressing cancers: Immunological effects and clinical activity
Clinical Cancer Research, 08/02/2012
Karbach J et al. – Mixed Bacterial Vaccine (MBV) at fever–inducing dose levels can lead to a massive induction of immuno–regulatory cytokines that may be involved in inducing tumor regressions. We propose to further explore the role of MBV as a potent immune modulator at higher dose levels and in conjunction with antigen–specific cancer vaccines.