Hyperpolarization-Activated Current (Ih) in Vestibular Calyx Terminals: Characterization and Role in Shaping Postsynaptic Events
Journal of the Association for Research in Otolaryngology, 08/20/2012
Meredith FL et al. – Hyperpolarizing current steps produced a time–dependent depolarizing sag followed by either a rebound afterdepolarization or an action potential. Spontaneous excitatory postsynaptic potentials (EPSPs) became larger and wider when I h was blocked with ZD7288. In a three–dimensional mathematical model of the calyx terminal based on Hodgkin–Huxley type ionic conductances, removal of I h similarly increased the EPSP, whereas cAMP slightly decreased simulated EPSP size and width.