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Associations of Bisphenol A Exposure With Heart Rate Variability and Blood Pressure
Hypertension, 08/02/2012
Clinical Article
Bae S et al. – The odds ratio of showing hypertension was 1.27 in the fourth quartile compared with the first quartile of urinary Bisphenol A concentration. When the analyses were restricted to participants who did not report previous history of hypertension, the odds ratio was increased to 2.35.
Methods- The authors recruited 560 noninstitutionalized elderly citizens from August 2008 to August 2010 in Seoul.
- All of the participants were ≥60 years old.
- The participants took medical examinations ≤5 times.
- Urinary BPA concentration, heart rate variability, and blood pressure were measured at each time.
- A total of 1511 observations from 521 participants were included in the analyses.
- The authors observed that urinary BPA was associated negatively with the root mean square of successive differences for heart rate and positively with blood pressure.
- The odds ratio of showing hypertension (systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg) was 1.27 (95% CI, 0.85–1.88) in the fourth quartile compared with the first quartile of urinary BPA concentration.
- When the analyses were restricted to participants who did not report previous history of hypertension (n=258), the odds ratio was increased to 2.35 (95% CI, 1.33–4.17).