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Does the relationship between natriuretic hormones and diastolic function differ by race
The American Journal of the Medical Sciences, 08/01/2012
Kapuku GK et al. – The higher correlations between levels of Natriuretic peptides (NP) and diastolic function indices both at rest and stress suggest that NP protective action is more pronounced in whites than in blacks.
Methods- To assess this, 55 (21 whites and 27 males) normotensive adults underwent a 2–hour protocol of 40 minutes rest, video game stressor and recovery.
- Mitral inflow and myocardial velocities (tissue Doppler) were recorded every 20 minutes.
- Blood pressure and heart rate were obtained at 10–minute intervals.
- Blood samples for pro–atrial NP and pro–brain NP (pro–BNP) were collected every 40 minutes.
- There were differences in the association between (1) the changes from rest to stress for E/A ratio and double product (whites, r = –0.42; blacks, r = 0. 10; P = 0.034 for difference between correlations); (2) stress Em and pro–atrial NP (whites, r = 0.59; blacks, r = –0.25; P = 0.025); (3) rest Em and BNP (whites, r = 0.83; blacks r = –0.17; P = 000); (4) rest Em/Am and pro–BNP (whites, r = 0.70; blacks, r = –0.42;; P = 0.003); (5) rest E/Em and pro–BNP (whites, r = –0.61; blacks, r = 0.31; P = 0.015) and (6) stress E and pro–BNP (whites, r = 0.56; blacks, r = –0.18; P = 0.043).