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Relationship between endothelial functions and acetylsalicylic acid resistance in newly diagnosed hypertensive patients Full Text
Clinical Cardiology, 07/31/2012
Sahin T et al. – Endothelial functions were impaired more in hypertensive patients compared to the control group. Endothelial functions were improved with all ASA doses in hypertensive patients irrespective of ASA resistance.
Methods- 58 hypertensive patients and 61 healthy subjects in the control group were included in the study.
- Endothelial functions of the patient and control groups were evaluated with brachial artery examination.
- Patient and control groups were divided into 2 groups.
- A total of 100 mg and 300 mg of aspirin were given to the separate groups for 1 week.
- After 1 week, endothelial functions were reevaluated and aspirin resistance examined with a platelet function analyzer (PFA–100; Dade Behring, Marbourg, Germany).
- Baseline flow–mediated dilatation (FMD) change percent in hypertensive patients was 9.8%, and it was significantly lower than in the control group (12%) (P < 0.001).
- Frequency of acetylsalicylic acid (ASA) resistance was 20% and 26% in control and hypertensive patient groups, respectively (P = not significant).
- ASA resistance was 28% and 24% in 100 mg and 300 mg in hypertensive patients, respectively (P = not significant).
- FMD change percent increased both in the control and hypertensive groups after ASA treatment from 12.4% to 13.3% and 9.8 % to 11.9 %, respectively.
- FMD percentage change was significantly increased in hypertensive patients irrespective of ASA resistance (P = 0.02, for ASA resistance [+]; P < 0.012, for ASA resistance [–]).