Higher Gamma-Aminobutyric Acid Neuron Density in the White Matter of Orbital Frontal Cortex in Schizophrenia
Biological Psychiatry, 08/01/2012
Joshi D et al. – The study provides evidence that pathology of interstitial white matter neurons in schizophrenia includes gamma–aminobutyric acid (GABA)ergic interneurons and that increased IWMN density may be related to GABAergic deficits in the overlying gray matter. These findings provide evidence at the cellular level that the orbitofrontal cortex is a site of pathology in schizophrenia and support the hypothesis that inappropriate migration of cortical inhibitory interneurons occurs in schizophrenia.