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The prevalence of atrial fibrillation in a geographically well-defined population in Northern Sweden: implications for anticoagulation prophylaxis
Journal of Internal Medicine, 08/17/2012
Andersson P et al. – Within this large Caucasian population, authors identified the highest community–based prevalence of atrial fibrillation (AF) to date. The prevalence was strongly associated with increasing age and male gender. Using CHA2DS2–VASc instead of CHADS2 widened the indication for oral anticoagulation (OAC) prophylactic therapy of AF in this population.
Methods- The study population was recruited from AURICULA, a Swedish national quality register for patients receiving anticoagulation treatment.
- All patients with the diagnosis AF in the catchment area are registered in AURICULA.
- Of the 65532 inhabitants in the catchment area, 1616 were diagnosed with AF (1200 cases were characterized as chronic AF).
- Thus, the overall prevalence of AF was 2.5%.
- The prevalence increased with age from 6.3% in patients over 55 years of age to 13.8% in those over 80 years.
- The prevalence was higher in men than in women in all age groups.
- Overall, 56.3% and 85.1% of the population were at high risk of stroke (≥2 points) according to CHADS2 and CHA2DS2–VASc, respectively.
- In addition, 26.9% had an increased bleeding risk according to HAS–BLED.