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Energy expenditure in patients with severe head injury: Controlled normothermia with sedation and neuromuscular blockade
Journal of Critical Care, 08/02/2012
Clinical Article
Osuka A et al. – Energy expenditure in patients with severe traumatic brain injury who need mechanical ventilation and have received controlled normothermia with sedation and neuromuscular blockade was 13% less than predicted basal levels. Energy expenditure might be obtained from age, body height, body weight, heart rate, and minute ventilation.
Methods- Ten patients with severe traumatic brain injury were studied.
- All patients received midazolam and vecuronium or pancuronium to control body temperature to 36.0°C.
- Energy expenditure was measured using indirect calorimetry.
- Age, body height, body weight, heart rate, blood pressure, body temperature, and minute ventilation volume were evaluated at the time of the study.
- Differences between the mean measured energy expenditures (MEEs) and predicted basal energy expenditures (PEEs from the Harris–Benedict equation) were analyzed using paired t test.
- Furthermore, the relationships between these variables and MEEs were analyzed with multiple regression analysis.
- The result of MEE was 1279±244kcal/d.
- When compared with PEE, MEE/PEE was 87.2%±10%.
- Multiple regression analysis showed that age, body height, body weight, heart rate, and minute ventilation volume were related with MEE.