High HbA1c levels correlate with reduced plaque regression during statin treatment in patients with stable coronary artery disease: Results of the coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS) Full Text
Cardiovascular Diabetology, 07/26/2012
Daida H et al. – Despite similar improvements in lipid levels, plaque regression was less pronounced in patients with high HbA1c levels compared with those with low levels. Tight glucose control during statin therapy may enhance plaque regression in patients with stable coronary disease.Methods
- In this subanalysis of COSMOS, authors examined the association between HbA1c and plaque regression in 40 patients with HbA1c [greater than or equal to]6.5% (high group) and 86 patients with HbA1c <6.5% (low group).
- In multivariate analyses, HbA1c and plaque volume at baseline were major determinants of plaque regression.
- LDL cholesterol decreased by 37% and 39% in the high and low groups, respectively, while HDL cholesterol increased by 16% and 22%, respectively.
- The reduction in plaque volume was significantly (p=0.04) greater in the low group (from 71.0+/–39.9 to 64.7+/–34.7 mm3) than in the high group (from 74.3+/–34.2 to 71.4+/–32.3 mm3).
- Vessel volume increased in the high group but not in the low group (change from baseline: +4.2% vs –0.8%, p=0.02).
- Change in plaque volume was significantly correlated with baseline HbA1c.