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Endotoxin-induced and vaccine-induced systemic inflammation both impair endothelium-dependent vasodilation, but not pulse wave reflection Full Text
Vascular Health and Risk Management, 08/01/2012
Lind L et al. – Despite the fact that endotoxin induced a more pronounced degree of inflammation than vaccination, both inflammatory challenges impaired endothelium–dependent vasodilation to a similar degree, supporting the view that different inflammatory stimuli could induce harmful effects on the vasculature.
Methods- Twelve young healthy males were studied at the same time of the day on three occasions in a random order; on one occasion 4 hours following an endotoxin injection (Escherichia coli endotoxin, 20 IU/kg), on another occasion 8 hours following vaccination against Salmonella typhi, and on a third occasion 4 hours following a saline control injection.
- EDV and endothelium–independent vasodilation (EIDV) were evaluated by local infusions of acetylcholine and sodium nitroprusside in the brachial artery, and forearm blood flow was measured with venous occlusion plethysmography.
- The augmentation index was determined by pulse wave analysis as an index of pulse wave reflection.
- Both endotoxin and vaccination impaired EDV to a similar degree compared with the saline control (P = 0.005 and P = 0.014, respectively).
- EIDV was not significantly affected by inflammation.
- Endotoxin, but not vaccination, increased body temperature and circulating levels of intracellular adhesion molecule–1 and interleukin–6.
- Augmentation index was not affected by the interventions.