Multicenter Automatic Defibrillator Implantation Trial: Reduce Inappropriate Therapy (MADIT-RIT): Background, Rationale, and Clinical Protocol
Annals of Noninvasive Electrocardiology, 08/02/2012
Schuger C et al. – The MADIT–RIT is a global, prospective, randomized, nonblinded, three–arm, multicenter clinical investigation to be performed in the Unites States, Europe, Canada, Israel and Japan, and will utilize approximately 90 centers with plan to enroll 1500 patients programmed to three treatment arms. The objective of the MADIT–RIT trial is to determine if dual–chamber implantable cardioverter defibrillator (ICD) or CRT–D devices with high rate cutoff and/or long delay in combination with detection enhancements are associated with fewer patients experiencing inappropriate therapies than standard programming during postimplant follow–up of patients with indication for primary prevention device therapy.