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Immune defense single nucleotide polymorphisms and recruitment strategies associated with contact lens keratitis
Ophthalmology, 08/02/2012
Carnt NA et al. – Genetic variation in DEFB1 that may lead to decreased protein expression of hBD–1 exhibits a tendency toward increased susceptibility and severity of contact lens–related keratitis. Investigation of these and other hBD genes that play important roles in animal models in a larger sample size is warranted. The approach of requesting samples from retrospective case series was generally feasible, although significant resources, including repeat phone calls, are required. More targeted strategies to recruit younger individuals to participate in genetic studies may be useful.