GSK3β Inhibition Blocks Melanoma Cell/Host Interactions by Downregulating N-Cadherin Expression and Decreasing FAK Phosphorylation
Journal of Investigative Dermatology, 08/08/2012
John JK et al. – The authors have, to their knowledge, demonstrated a previously unreported role for glycogen synthase kinase (GSK)–3β in modulating the motile and invasive behavior of melanoma cells through N–cadherin and focal adhesion kinase. These studies suggest the potential therapeutic utility of inhibiting GSK3β in defined subsets of melanoma.