Simultaneous PET–MRI in oncology: a solution looking for a problem
Magnetic Resonance Imaging, 08/01/2012
Peterson TE et al. – The authors highlight several of the key areas where integrated positron emission tomography–magnetic resonance imaging (PET–MRI) measurements, obtained simultaneously, are anticipated to have a significant impact on clinical and/or research studies. These areas include the use of MR-based motion corrections and/or a priori anatomical information for improved reconstruction of PET data, improved arterial input function characterization for PET kinetic modeling, the use of dual-modality contrast agents, and patient comfort and practical convenience. For widespread acceptance, a compelling case could be made if the combination of quantitative MRI and specific PET biomarkers significantly improves the ability to assess tumor status and response to therapy, and some likely candidates are now emerging.