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Outcome of Patients with Platelet-Derived Growth Factor Receptor Alpha–Mutated Gastrointestinal Stromal Tumors in the Tyrosine Kinase Inhibitor Era
Clinical Cancer Research, 07/17/2012
Cassier PA et al. – This study is the largest reported to date on patients with advanced Platelet–derived growth factor receptor–alpha (PDGFRA)–mutant gastrointestinal stromal tumors (GIST) treated with imatinib. The data confirm that imatinib has little efficacy in the subgroup of patients with D842V substitution in exon 18, whereas other mutations appear to be sensitive to imatinib.