NELL-1-dependent mineralisation of Saos-2 human osteosarcoma cells is mediated via c-Jun N-terminal kinase pathway activation
International Orthopaedics, 07/17/2012
Chen F et al. – Activation of the JNK pathway is necessary to mediate terminal osteogenic differentiation of Saos–2 osteosarcoma cells by rhNELL–1. Future studies will extend these in vitro mechanisms to the in vivo effects of NELL–1 in dealing with orthopaedic defects caused by skeletal malignancies or other aetiologies.