Update on the pathogenesis of complex regional pain syndrome: Role of oxidative stress
Canadian Journal of Anesthesia, 07/17/2012
Taha R et al. – Recent evidence demonstrates that oxidative stress is associated with clinical symptoms in patients with CRPS-I. Oxidative stress plays a key role in CRPS pathogenesis. The Nrf2 factor is a master regulator of the transcription of multiple antioxidants, which protects against oxidative stress and inflammation by inducing antioxidant and detoxifying genes through binding with an antioxidant response element.