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Hemoglobin A1c and the relationship to stage and grade of endometrial cancer
Archives of Gynecology and Obstetrics, 07/18/2012
Stevens EE et al. – Elevated preoperative HgA1c has a trend toward a higher stage at the time of diagnosis. Advanced stage is a poor prognostic measure for overall survival.
Methods- A retrospective chart review was performed from January 2000 to June 2010 at three academic medical centers.
- Patients were included if they underwent surgical staging and had HgA1c drawn within 3 months before surgery.
- Demographic data, fasting blood glucose levels and overall survival data were also obtained.
- Eighty-two patients fitting the inclusion criteria were identified during the study period.
- There was a strong positive correlation between HgA1c and fasting glucose.
- There was no statistical difference with regard to stage alone, grade alone, or when stratified together with regard to HgA1c or fasting glucose levels.
- There was a trend toward increased mean HgA1c across increasing stages, but this was not statistically significant.
- Diabetes, HgA1c and tumor grade did not affect overall survival, but advanced stage was a poor prognostic measure for overall survival.