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Soy Milk Consumption, Inflammation, Coagulation, and Oxidative Stress Among Type 2 Diabetic Patients With Nephropathy
Diabetes Care, 07/31/2012
Miraghajani MS et al. – Soy milk consumption could decrease serum d–dimer level among type 2 diabetic patients with nephropathy. However, markers of inflammation and oxidative stress did not change following soy milk intake among these patients.
Methods- This randomized, crossover clinical trial was conducted on 25 type 2 diabetic patients with nephropathy.
- This study had two trial phases, each for 4 weeks and one washout period for 2 weeks.
- Patients were randomly assigned to consume a diet containing soy milk or a diet containing cow’s milk.
- Soy milk consumption resulted in a significant reduction in d-dimer level (percent change: -3.77 vs. 16.13%; P < 0.05).
- This significant effect remained even after adjusting for confounding factor (carbohydrate intake).
- However, soy milk consumption had no significant effects on tumor necrosis factor-α, interleukin-6, high sensitivity C-reactive protein (hs-CRP), and malondialdehyde levels.
- The result was near to significance regarding the effect of soy milk consumption on hs-CRP (percent change: -35.45 vs. 36.76%; P = 0.05).
- However, this effect was not significant after adjusting for the confounding variable (carbohydrate intake).