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Magnesium sulphate: an adjuvant to tracheal intubation without muscle relaxation – a randomised study
European Journal of Anaesthesiology, 07/18/2012
Clinical Article
Aissaoui Y et al. – Addition of magnesium sulphate to propofol and fentanyl at induction of anaesthesia significantly improved intubating conditions without administration of a neuromuscular blocking drug.
Methods- Sixty patients with American Society of Anesthesiologists physical status 1/2 scheduled for elective surgery under general anaesthesia were included.
- Before induction of general anaesthesia, patients were assigned to receive either a 10min infusion of magnesium sulphate 45mgkg–1 in 100ml of isotonic saline (magnesium group, n=30) or the same volume of saline (control group, n=30).
- Anaesthesia was induced with fentanyl 3µgkg–1 followed 3min later by propofol 2.5mgkg–1.
- Intubating conditions were evaluated by a blinded anaesthesiologist using the criteria of the Copenhagen consensus conference: ease of laryngoscopy, vocal cord position and/or movement and response to intubation or cuff inflation (cough or diaphragmatic movement).
- Intubating conditions were considered as acceptable (excellent or good) or unacceptable (poor).
- Mean arterial pressure and heart rate were also recorded during the study period.
- The two groups were comparable in their demographic profiles.
- Clinically acceptable intubating conditions were observed more frequently in the magnesium group than in the control group: 25 (83%) vs. 18 patients (60%) (P=0.042).
- There was no failed intubation.
- There were no differences between the groups with regard to haemodynamic variables.