Amplitude-Integrated Electroencephalography in Newborns with Inborn Errors of Metabolism
Olischar M et al. – Amplitude–integrated electroencephalography (aEEG) in patients with inborn errors of metabolism frequently reveals abnormalities and assists clinicians in the clinical assessment, management and monitoring of these patients.Methods
- Cases collected through an international registry were divided into 5 groups of metabolic disorders.
- Common aEEG features were sought for each group.
- Patients with disorders of energy metabolism, hyperammonemia, and organic/amino acidopathies often showed marked aEEG depression with seizure activity.
- In contrast, aEEGs of patients with peroxisomal disorders did not show major background abnormalities but seizures were present in 5/6 subjects.