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Genetics of Type 2 Diabetes in European Populations
Journal of Diabetes, 07/17/2012
Qi Q et al. – Although the recent discovery of novel Type 2 diabetes (T2D) susceptibility loci has contributed substantially to the understanding of the pathophysiology of the disease, clinical utility of these loci in disease prediction and prognosis is limited. More studies using multiethnic meta–analysis, gene–environment interaction analysis, sequencing analysis, epigenetic analysis, and functional experiments are needed to identify new susceptibility T2D loci and causal variants and to establish biological mechanisms.