Cap-dependent mRNA translation and the ubiquitin-proteasome system cooperate to promote ERBB2-dependent esophageal cancer phenotype
Cancer Gene Therapy, 07/11/2012
Issaenko OA et al. – The data support the hypothesis that a finely tuned balance between eIF4F–driven protein synthesis and proteasome–mediated protein degradation is required for the maintenance of ERBB2–mediated esophageal adenocarcinoma (EAC) malignant phenotype. Altogether, the study supports the development of pharmaceuticals to directly target eIF4F as most efficient strategy; and provides a clear rationale for the clinical evaluation of combination therapy with m–TOR inhibitors and bortezomib for EAC treatment.