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Is plasma urotensin II concentration an indicator of myocardial damage in patients with acute coronary syndrome
Archives of Medical Science, 07/11/2012
Clinical Article
Babinska M et al. – Decreased plasma urotensin II concentration in patients with acute coronary syndrome (ACS) could be associated with more severe injury of myocardium.
Methods- One hundred and forty–nine consecutive patients with ACS, without age limit, were enrolled in the study.
- In all patients plasma concentration of creatinine, creatine kinase isoenzyme MB (CK–MB), troponin C, N–terminal prohormone of brain natriuretic peptide (NT–pro BNP), and UII were assessed, and echocardiography was performed in order to assess the degree of left ventricular hypertrophy, ejection fraction (EF) and mass (LVM).
- In patients with the highest risk (TIMI 5–7) plasma UII concentration was significantly lower than in those with low risk (TIMI 1–2): 2.61 ±1.47 ng/ml vs. 3.60 ±2.20 ng/ml.
- Significantly lower plasma UII concentration was found in patients with increased concentration of troponin C (2.60 ±1.52 ng/ml vs. 3.41 ±2.09 ng/ml).
- There was a significant negative correlation between plasma UII concentration and TIMI score or concentration of troponin C, but not CK–MB.
- Borderline correlation between plasma UII and ejection fraction (R = 0.157; p = 0.063) or NT–proBNP (R = –0.156; p = 0.058) was found.