Insular dysfunction and descending pain inhibition in anorexia nervosa
Acta Psychiatrica Scandinavica, 07/03/2012
Bar KJ et al. – The authors suggest that reduced activity in the left posterior insula might contribute to increased pain thresholds in patients, while increased activations in the right anterior insula and pons mirror augmented sympathetic modulation putatively related to amplification of adrenergic descending pain inhibition. In addition, pain thresholds and brain activations were influenced by disease–inherent depressed mood.