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Does optic nerve head size variation affect circumpapillary retinal nerve fiber layer thickness measurement by optical coherence tomography
Investigative Ophthalmology & Visual Science, 06/29/2012
Clinical Article
Huang D et al. – There is no significant association between retinal nerve fiber layer (RNFL) thickness and optic disc area. Previous publications that showed such association may have been biased by the effect of axial length on fundus image magnification and therefore both measured RNFL thickness and apparent disc area. The true diameter of the circumpapillary OCT scan is larger for a longer eye, leading to a thinner RNFL measurement. Adjustment of measured RNFL thickness by axial length, in addition to age, may lead to a tighter normative range and improve the detection of RNFL thinning due to glaucoma.