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Does the degree of hypothalamic-pituitary-ovarian recovery after oral contraceptive pills affect outcomes of IVF/ICSI cycles receiving GnRH-antagonist adjuvant therapy in women over 35 years of age
Journal of Assisted Reproduction and Genetics, 06/26/2012
Schmitz C et al. – The results of this study provide data that assist in clinical management. Gonadotropin serum levels after OCP treatment provide information for optimization of supplementation with LH in GnRH–antagonist cycles in women over age 35.
Methods- In this retrospective cohort study, they included 98 women 35–42 years undergoing their first IVF cycle receiving gonadotropins and a fixed GnRH–antagonist adjuvant protocol.
- Data analysis was carried out according to changes in serum FSH, LH and estradiol (E2) levels (basal and post–OCP) divided in quartiles, and also according to absolute levels.
- The main outcomes were peak serum E2, number of mature oocytes retrieved, length of stimulation, and amount of gonadotropins used.
- By quartile analysis, patients with the highest levels of serum gonadotropins suppression and also patients with gonadotropin rebound needed larger amounts of LH during the treatment.
- On the other hand, women with absolute suppression of FSH/LH had increased length of stimulation.