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Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis Full Text
Arthritis Research & Therapy, 06/26/2012
Teruel M et al. – The results do not suggest an important role of CD40 and CD40LG gene polymorphisms in the susceptibility or clinical expression of systemic sclerosis (SSc).
Methods- A total of 2,670 SSc patients and 3,245 healthy individuals from 4 European populations (Spain, Germany, The Netherlands and Italy) were included in the study.
- A total of 5 single nucleotide polymorphisms (SNPs) of the CD40 (rs1883832, rs4810485, rs1535045) and CD40LG (rs3092952, rs3092920) were genotyped using a predesigned TaqMan allele discrimination assay technology.
- Meta–analysis was assessed to determine whether there is an association between the genetic variants and SSc or its main clinical subtypes.
- No evidence of association between CD40 and CD40LG genes variants with susceptibility of SSc was observed.
- Similarly, no significant statistical differences were observed when SSc patients were stratified by the clinical subtypes, the serological features and pulmonary fibrosis.