Dexamethasone versus ondansetron in combination with dexamethasone for the prophylaxis of postoperative vomiting in pediatric outpatients: a double-blind, randomized, placebo-controlled clinical trial
Paediatric Anaesthesia, 06/26/2012
de Orange FA et al. – The prophylactic use of antiemetic drugs failed to reduce the incidence of postoperative vomiting (POV) in pediatric outpatient surgery with a low emetic potential; therefore, routine prophylaxis may be unnecessary.Methods
- This double–blind, randomized, placebo–controlled clinical trial included 129 children.
- The participants were randomized into three prophylactic treatment groups: dexamethasone (n=43), ondansetron in combination with dexamethasone (n=44), and placebo (n=42).
- The variables studied were the frequency of POV and the incidence of vomiting after the patient had been discharged from hospital, the need for antiemetic rescue therapy in the postanesthesia care unit (PACU), need for hospitalization, and the time the patient remained in the PACU.
- A significance level of 5% was adopted.
- Postoperative vomiting occurred in 12.4% of the children, with no statistically significant difference between the groups: 6.8% in the group receiving ondansetron combined with dexamethasone, 14.3% in the placebo group, and 14% in the group that received dexamethasone alone (P=0.47).
- Furthermore, no significant difference was found between the groups with respect to the time the children remained in the PACU, and only five patients reported having vomited following discharge from hospital.