25 hydroxyvitamin D levels in patients undergoing coronary artery catheterization
European Journal of Internal Medicine , 07/06/2012
Shor R et al. – 25(OH)D deficiency is significantly associated with pathological cardiac catheterization findings. This association is strengthened further by controlling for other cardiovascular disease risk factors.Methods
- An observational study of 101 consecutive patients admitted to Assaf Harofeh Medical Center during 2009, and scheduled to undergo coronary catheterization was undertaken.
- Blood was collected for parathyroid hormone, 25(OH)D and high sensitivity C reactive protein (hsCRP).
- 25(OH)D deficiency was defined as <20ng/ml.
- Patients were divided into two groups: patients with normal or non–significant coronary artery disease and patients with a significant coronary artery disease as found during cardiac catheterization.
- Logistic regression model was used to compare pathological coronary catheterization findings, including 25(OH)D levels dichotomized to low (serum 25(OH)D levels<20ng/ml) vs. high (serum 25(OH)D levels<20ng/ml) and other confounders.
- Patients with pathological coronary catheterization had 25(OH)D deficiency (75% vs 55.1%, p=0.036).
- Pathological coronary catheterization was more prevalent among patients with 25(OH)D deficiency (Odds ratio (OR) 2.44, 95% confidence interval (CI) 1.05–5.68, p=0.038).
- This difference was more pronounced after controlling for sex, age, BMI, ethnicity and present smoking (OR 2.92, 95% CI 1.01–8.46, p=0.016).