Low-level laser in the treatment of patients with hypothyroidism induced by chronic autoimmune thyroiditis: a randomized, placebo-controlled clinical trial
Lasers in Medical Science, 06/29/2012
Hofling DB et al. – The findings suggest that low–level laser therapy (LLLT) was effective at improving thyroid function, promoting reduced thyroid peroxidase antibodies (TPOAb)–mediated autoimmunity and increasing thyroid echogenicity in patients with chronic autoimmune thyroiditis (CAT) hypothyroidism.Methods
- A randomized, placebo–controlled trial with a 9–month follow–up was conducted from 2006 to 2009.
- Forty–three patients with a history of levothyroxine therapy for CAT–induced hypothyroidism were randomly assigned to receive either 10 sessions of LLLT (830 nm, output power of 50 mW, and fluence of 707 J/cm2; L group, n = 23) or 10 sessions of a placebo treatment (P group, n = 20).
- The levothyroxine was suspended 30 days after the LLLT or placebo procedures.
- Thyroid function was estimated by the levothyroxine dose required to achieve normal concentrations of T3, T4, free–T4 (fT4), and thyrotropin after 9 months of postlevothyroxine withdrawal.
- Autoimmunity was assessed by measuring the TPOAb and TgAb levels.
- A quantitative computerized echogenicity analysis was performed pre– and 30 days postintervention.
- The results showed a significant difference in the mean levothyroxine dose required to treat the hypothyroidism between the L group (38.59±20.22 μg/day) and the P group (106.88±22.90 μg/day, P < 0.001).
- Lower TPOAb (P = 0.043) and greater echogenicity (P < 0.001) were also noted in the L group.
- No TgAb difference was observed.