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Environmental tobacco smoke and stress as risk factors for miscarriage and preterm births
Archives of Gynecology and Obstetrics, 07/05/2012
Arffin F et al. – The results from this primarily study demonstrated no association between cotinine, cortisol, miscarriage and preterm births.
Methods- A total of 33 subjects consisted of multiparous pregnant women that were in their early third trimester were chosen for this investigation.
- Subjects were divided into test group women with adverse pregnancy outcome, control group women with successful pregnancy.
- Four ml of unstimulated whole saliva were collected.
- The concentrations of cotinine and cortisol were evaluated using commercially available ELISA kit.
- Pregnancies in which the average standardized cortisol during history of previous miscarriage(s) which occurred within 6th–27th week or/and history of preterm labor which occurred within 28th–36th weeks of gestation, demonstrated higher cortisol level (1.0201 ± 0.1855 ng/ml) compared to control group 0.9757 ± 0.2860 ng/ml (P = 0.323); statistical analysis showed no significant differences.
- Women of control group were more likely to be environmental tobacco smoke exposed (1.2714 ± 1.7639 ng/ml) than women with miscarriage and preterm births (0.9889 ± 0.5498 ng/ml).