Calcium-activated chloride channels in the corpus cavernosum: recent developments and future of a key cellular component of the erectile process
International Journal of Impotence Research: The Journal of Sexual Medicine, 06/22/2012
Linton DJ et al. – Several studies identified specific inhibitors of calcium–activated chloride channels (CaCCs) as well as specific inhibitors for anoctamin–1. Despite the number of recent achievements in this field there are many details that still need to be elucidated. Of particular value would be more details on the identity of the CaCCs in corpus cavernosum smooth muscle, using new inhibitors to gain insight into the signalling pathway, and the evaluation of whether inhibition of CaCCs provides any specific benefit in different models of ED.