Pheidippides Redux: Reducing Risk for Acute Cardiac Events During Marathon Running
American Journal of Medicine, 06/26/2012
Siegel AJ – A hemostatic imbalance with prothrombotic effects includes in vivo platelet activation during the race. Suggesting a pathogenic role for these findings, plaque rupture due to atherothrombosis triggers acute exertional cardiac events, including sudden death, in low–risk runners as in high–risk patients such as those with diabetes mellitus. Strategies including prophylactic aspirin are considered to decrease the risk for acute cardiac events.