Impact of PGL-I Seropositivity on the Protective Effect of BCG Vaccination among Leprosy Contacts: A Cohort Study Full Text
PLoS Neglected Tropical Diseases, 06/20/2012
Duppre NC et al. – The presence of antibodies against a specific Mycobacterium leprae antigen (PGL–I) at the first examination and BCG vaccination status were evaluated. PGL–I–positive contacts had a higher risk of developing leprosy than PGL–I–negative contacts. Among the former, vaccinated contacts were at higher risk than unvaccinated contacts. The results indicate that contact examination combined with PGL–I testing and BCG vaccination appears to justify the targeting of PGL–I–positive individuals for enhanced surveillance.