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Frequency of Helicobacter pylori-Negative Gastric Cancer and Gastric Mucosal Atrophy in a Japanese Endoscopic Submucosal Dissection Series Including Histological, Endoscopic and Serological Atrophy
Digestion, 06/26/2012
Clinical Article
Ono SS et al. – Early gastric cancers in the Japanese endoscopic submucosal dissection series were strongly related to current or past infection with H. pylori and to gastric mucosal atrophy.
Methods- A total of 240 early gastric cancers were included in this study.
- The status of H. pylori infection was determined from the rapid urease test, 13C-urea breath test, H. pylori culture, histopathological examination and examination of IgG antibodies.
- In H. pylori-negative gastric cancer, histological atrophy and intestinal metaplasia, endoscopic atrophy and serological atrophy were assessed by pepsinogen.
- The rate of H. pylori infection was 77.9% and 19 patients (7.9%) had a history of eradication.
- 34 patients (14.2%) were diagnosed with H. pylori-negative gastric cancer using diagnostic tools of H. pylori.
- However, most of the patients with H. pylori-negative gastric cancer had histological atrophy and intestinal metaplasia.
- Only 1 gastric cancer (0.42%) occurred in the mucosa without histological atrophy, endoscopic atrophy or serological atrophy.