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Circulating Immunoglobulins, Leucocytes and Complements in Childhood-onset Atopic Eczema
The Indian Journal of Pediatrics, 06/20/2012
Hon KL et al. – Blood levels of IgE, IgA, IgG,eosinophils, lymphocytes, neutrophils and complements pathophysiologically correlate with eczema severity. Eosinophil/lymphocyte ratio may represent a readily–available objective laboratory correlate of eczema severity. Eczema is a complex atopic disease involving many cellular and humoral components of the immune system.
Methods- White cell differentials, levels of serum immunoglobulins and complements of patients with eczema and miscellaneous non-eczema skin diseases were measured.
- Eczema severity and quality of life were assessed by SCORAD, Nottingham Eczema Severity Score (NESS) and Children’s Dermatology Life Quality Index (CDLQI).
- Correlations were analyzed by Pearson’s correlation test for parametric data and Spearman’s rho correlation test for non-parametric data.
- Serum IgE and peripheral blood eosinophil percentage were significantly higher in patients with eczema than other non-eczema skin diseases.
- Levels of IgE (log-transformed), IgA and IgG correlated with objective SCORAD (r=0.52, 0.40, 0.29, respectively).
- Levels of eosinophil, neutrophils, lymphocytes and complements also correlated with objective SCORAD, with the eosinohil/lymphocyte ratio showing the highest correlation (r=0.60, p<0.01).
- Ratios of IgE/IgA, IgE/IgG, eosinophils/lymphocytes, eosinophils/neutrophils correlated positively with CDLQI.
- IgM appeared to have no correlation with eczema.