Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia Full Text
The Journal of Clinical Investigation, 07/03/2012
Shen HY et al. – Intrastriatal implants of engineered adenosine–releasing cells restored the locomotor response to amphetamine in mice overexpressing ADK, whereas the same grafts placed proximal to the hippocampus of transgenic mice reversed their working memory deficit. This functional double dissociation between striatal and hippocampal adenosine demonstrated in Adk transgenic mice highlights the independent contributions of these two interconnected brain regions in the pathophysiology of schizophrenia and thus provides the rationale for developing local adenosine augmentation therapies for the treatment of schizophrenia.