Hepatitis B virus X protein (HBx) modulates oncogene YAP via CREB to promote growth of hepatoma cells
Hepatology, 06/22/2012
Zhang T et al. – Yes–associated protein (YAP) is a key driver gene in the HBx–induced hepatocarcinogenesis in a cAMP response element–binding protein (CREB)–dependent manner. YAP may serve as a novel target in hepatitis B virus (HBV)–associated hepatocellular carcinogenesis (HCC) therapy.



