Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program
Cell Host & Microbe, 06/29/2012
Tattoli I et al. – In addition, bacteria–induced AA starvation activated the GCN2 kinase, eukaryotic initiation factor 27alpha;, and the transcription factor ATF3–dependent integrated stress response and transcriptional reprogramming. Thus, AA starvation induced by bacterial pathogens is sensed by the host to trigger protective innate immune and stress responses.