Serial changes in adiponectin and resistin in critically ill patients with sepsis: Associations with sepsis phase, severity, and circulating cytokine levels
Journal of Critical Care, 06/15/2012
Vassiliadi DA et al. – Adiponectin and resistin change reciprocally during the course of sepsis. Resistin relates to the severity of sepsis and the degree of inflammatory response. Adiponectin and resistin may play a critical role in the metabolic adaptations observed in sepsis.Methods
- An observational prospective study was conducted in a secondary/tertiary unit.
- Forty–one mechanically ventilated patients diagnosed as having sepsis were included in the study.
- The Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment scores were estimated.
- Adiponectin, resistin, and cytokines were measured upon sepsis diagnosis and every 3 to 4days thereafter until day 30.
- Adiponectin and resistin were also measured in 40 controls.
- The patients had higher adiponectin (10.9±6.1µg/mL vs 6.0±2.9µg/mL, P<.001) and resistin (24.7ng/mL vs 3.8ng/mL, P<.001) levels compared with the controls.
- Adiponectin increased and resistin decreased significantly over time in the entire cohort.
- Resistin correlated with Acute Physiology and Chronic Health Evaluation II, Sequential Organ Failure Assessment, interleukin (IL)–6, IL–8, and IL–10 and was significantly higher in severe sepsis/septic shock compared with sepsis.
- No correlations between adiponectin and clinical scores were noted.