Postprandial Platelet Activation Is Related to Postprandial Plasma Insulin Rather Than Glucose in Patients With Type 2 Diabetes Mellitus Full Text
Spectre G et al. - The results suggest that postprandial insulin rather than glucose accounts for postprandial platelet activation in type 2 diabetes mellitus (T2DM) patients.Methods
- A randomized, double-blind, cross-over study was performed to compare postprandial platelet activation after premeal injections of placebo or insulin aspart (0.1 and 0.2 units/kg) in 18 patients with type 2 diabetes mellitus (T2DM).
- Platelet activation was assessed by flow cytometry, without and with stimulation by the thromboxane analog U46619 or ADP.
- Measurements were before and after premeal blood glucose standardization (to 6–7 mmol/L by insulin infusion, if needed) and at 90 min after the meal.
- Premeal insulin reduced postprandial hyperglycemia by 2–3 mmol/L compared with placebo.
- Postmeal insulin levels were doubled with placebo and further elevated with insulin injections.
- The standardized meal enhanced U46619-induced platelet P-selectin expression by 23% after placebo; this response was more than doubled after premeal insulin.
- U46619-induced fibrinogen binding was unchanged after meal intake with placebo but was markedly enhanced (by ~50–60%) after premeal insulin.