PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca2+ sensitivity
Journal of Molecular and Cellular Cardiology, 06/20/2012
Ullrich ND et al. – Authors show here by three independent experimental approaches that PKA–dependent RyR2–S2808 phosphorylation plays significant functional roles at the subcellular level, namely, Ca2+ release synchronization, Ca2+ wave propagation and functional adaptation of RyR2 to variable [Ca2+]SR. These results indicate a direct mechanistic link between RyR2 phosphorylation and SR luminal Ca2+ sensing.