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Long-term Outcome of Cognitive Functions, Emotional Behavior, and Quality of Life in a Family With Familial Hemiplegic Migraine
Cognitive and Behavioral Neurology, 06/29/2012
Clinical Article
Karner E et al. – Cognitive deficits in a family with familial hemiplegic migraine (FHM) persisted, but without marked progression. Worsening of visuoconstructional abilities may be related to executive dysfunction, confirming a disturbance of cerebrocerebellar circuits.
Methods- Seven years after extensive baseline neuropsychological testing, the authors retested 6 members of a family with FHM, including questionnaires about mood and quality of life.
- The follow–up assessment revealed no global cognitive decline.
- All the patients' linguistic abilities and verbal memory remained intact; however, their figural memory, attention, and some aspects of executive function were impaired.
- Half the patients had a slight deterioration in their visuoconstructional functions.
- Half had higher scores on the trait and state anxiety measures.