Pathology after Eculizumab in Dense Deposit Disease and C3 GN
Journal of the American Society of Nephrology, 06/08/2012
Herlitz LC et al. – Staining of the γ heavy chain was restricted to the IgG2 and IgG4 subclasses, suggesting the binding of monoclonal eculizumab to C5 in renal tissues. The long–term effects of this apparent drug–tissue interaction are unknown.