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Meta-Analysis of Association between Particulate Matter and Stroke Attack
CNS Neuroscience & Therapeutics, 06/22/2012
Clinical Article
Li XY et al. – The authors found some evidence for an effect of air pollutants on stroke attack risk.
Methods- Twelve quantitative studies about the associations between particulate matter and stroke attack met the inclusive criteria.
- The authors evaluated the odds ratio (OR) of stroke attack associated with per 10 μg/m3 increase of the concentration of PM10 (particulate matter with aerodynamic diameter ≤ 10 μm) or PM2.5 (particulate matter with aerodynamic diameter ≤ 2.5 μm) as effect scale, and a sensitivity analysis for the results was conducted.
- In the time–series design, PM10 exposure wasn't related to an increased risk of daily stroke attack [OR per 10 μg/m3=1.002, 95% confidence interval (CI): 0.999–1.005], PM2.5 exposure were related to an increased risk of daily stroke attack (OR per 10 μg/m3=1.006, 95%CI: 1.002–1.010]; but in the case–crossover studies, PM10 exposure was related to increase in risk of daily stroke attack (OR per 10 μg/m3=1.028, 95%CI: 1.001–1.057).
- PM2.5 exposure was not significant association with daily stroke attack (OR per 10 μg/m3=1.016, 95%CI: 0.937–1.097).
- Sensitivity analysis showed that the results for PM10, PM2.5 and daily stroke attack were robust in the time–series design.