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Correlation between Ki-67 immunohistochemistry and 18F-Fluorothymidine uptake in patients with cancer: A systematic review and meta-analysis
European Journal of Cancer, 06/20/2012
Evidence Based Medicine
Chalkidou A et al. – This systematic review and meta–analysis highlights the importance of the methods used in validation studies comparing FLT–PET imaging with the biomarker Ki–67. The correlation is significant and independent of cancer type provided a study design that uses Ki–67 average measurements, regardless of nature of sample, or whole surgical samples when measuring Ki–67 maximum expression. Sufficient data to support a strong correlation for brain, lung and breast cancer exist. However, larger, prospective studies with improved study design are warranted to validate these findings for the rest of the cancer types.